A study by Ma and co-workers on rat primary microglia cells N9 reported that 10 μM AM1241 was able to reduce LPS (10 ng/mL)/IFN-γ (10 U/mL)-induced microglial activation by switching the phenotype of microglia from the M1 to M2 state [75], indicating its ability to counteract the AD-related inflammatory response. This evidence concerns the gene IFNG and Alzheimer disease.