IGF1 and colorectal carcinoma: A proteomics analysis reported that 36 proteins were upregulated in the serum exosomes of CRC patients (e.g., alpha-1-antitrypsin (SERPINA1), alpha-2-antiplasmin (SERPINF2), and complement C9 (C9)), while 22 were downregulated, such as the integrin-mediated cell adhesion pathway, fibroblast growth factor receptor 1 (FGFR1), insulin-like growth factor 1 (IGF1), vitronectin (VTN), and chaperonin heat shock protein 90 (Hsp90) [49].