CXCL8 and neoplasm: Moreover, recent data have shown that exosomes may transfer the well-known CRC biomarker mutant KRAS to cells that only produce wild-type KRAS, [53], and exosomes isolated from cells with mutant KRAS significantly increase the cancer-related molecules, including inflammatory cytokines, such as interleukin 8 (IL-8) [54] and IL 6 [55], encouraging neutrophil recruitment, and hence inflammation in the tumor microenvironment, as well as adjacent cells in CRC.