NR1H4 and metabolic dysfunction-associated steatohepatitis: In addition, a rat model of MCD-induced NASH showed that calycosin inhibited the activation of HSCs by activating FXR and promoted the expression of PPARa, CPT1, Syndecan-1 and LPL, which are involved in the β-oxidation of free fatty acids, thereby reducing triglyceride accumulation and LF [140].