SYP and Alzheimer disease: Wu Cong and colleagues [52] used Aβ25-35 to establish an animal model of AD in order to investigate the effects of ginsenoside Rg2 on the structure of hippocampal neurons and synaptophysin (SY) expression in the rat hippocampus of the AD model group, and observed a significant reduction in the number of hippocampal neurons in the AD rats, light SY immunohistochemical staining, increased heterochromatin in the nucleus of neurons, swollen intracytoplasmic mitochondria, broken ridges, and the appearance of lipofuscous granules.