AKT1 and cardiovascular disorder: Saponins are widely distributed in nature, and it has been found that saponins extracted from traditional Chinese medicines have various pharmacological activities, such as anti-tumor [77], anti-inflammatory [78], anti-cancer [79], prevention and treatment of cardiovascular diseases [80], and that Ginsenoside Rg3 protects the myocardium through the Akt/eNOS signaling pathway and increases the Bcl-2/Bax ratio [81].