CAV1 and early-onset autosomal dominant Alzheimer disease: Regarding the relevance of caveolin-enriched domains in brain neurons in in vivo studies, some of them have shown a correlation between Cav-1–knocking down (Cav-1–KD) and the disruption of Cav-1-enriched membrane domains found in neurodegenerative diseases, such Alzheimer’s disease where an alteration of signaling processes associated with lipid membrane domains has been also described [118].