TNF and rheumatoid arthritis: Another flavanone, neohesperidin (hesperetin-7-neohesperidoside), has demonstrated anti-inflammatory effects by reducing the levels of proinflammatory cytokines IL-1β, IL-6, IL-8, TNF-α, and metalloproteinases MMP-3, MMP-9, and MMP-13 in TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.