APOE and obesity due to melanocortin 4 receptor deficiency: In this study, we demonstrate for the first time that long-term EGCG intervention reduces PFDA-exacerbated obesity and hepatic lipid accumulation in HFD-fed mice, which is consistent with the findings in apolipoprotein E knockout mice and HFD- and streptozotocin-induced type 2 diabetic mice [44,45].