GSDMD-dependent pyroptosis has been recently characterized in acute kidney injury, myocardial infarction, myocardial ischemia–reperfusion, pathological cardiac hypertrophy, and atherosclerosis, but the role of GSDMD-dependent pyroptosis in diabetes-mediated cardiac remodeling and underlying mechanisms have not been assessed in detail. This evidence concerns the gene GSDMD and atherosclerosis.