TF and liver cancer: It was also exhibited that the uptake of Tf-LP-CA on liver cancer cells HepG2 (p < 0.05) and SMMC-7721 (p < 0.01) was significantly higher than that of LP-CA, whereas there was no significant difference between the uptake of LP-CA and Tf-LP-CA by normal liver cells L-02, suggesting that Tf-LP-CA targeting is primarily through the Tf-R.