In 2014, it was reported that NGLY1 deficiency could lead to NGLY1-congenital disorder of deglycosylation (CDDG), a disease characterized by developmental delay, intellectual disability, absence of or reduced tears and sweating, abnormal liver function, and motor dysfunction [6,7,8]. Here, NGLY1 is linked to Alacrimia-choreoathetosis-liver dysfunction syndrome.