In 2014, it was reported that NGLY1 deficiency could lead to NGLY1-congenital disorder of deglycosylation (CDDG), a disease characterized by developmental delay, intellectual disability, absence of or reduced tears and sweating, abnormal liver function, and motor dysfunction [6,7,8]. The gene discussed is NGLY1; the disease is congenital disorder of deglycosylation 1.