Ah-Won Kwak et al. [47] used oxaliplatin-susceptible and resistant tumor cells as a model and found that echinatin induced ROS-mediated apoptosis through the JNK/p38 MAPK signaling pathway after administration of 5–15 μm doses and still showed good anti-cancer activity against tumor cells of resistant strains. The gene discussed is MAPK8; the disease is neoplasm.