AKT1 and neoplasm: In SW480 cells, Xian Shao et al. [45] found that 6,8-diprenylorobol is involved in the activation of the Akt/mTOR signaling pathway and initiates the activation of caspase-3, a key protein in apoptosis, in addition to modulating FOXO3 transcription factor activity, and confirmed that the isoprenyl group is the dominant structural motif for the anti-tumor effect of this ingredient, as shown in Figure 7.