MMP9 and neoplasm: It has also been shown to inhibit tumor cell proliferation, invasion, and metastasis by modulating the Ras/Raf/MEK and PI3K/Akt signaling pathways, which mediate a reduction in the expression of MMP2, MMP9, N-cadherin, Bcl-2, caspase, and other related proteins [66,67,68,69].