Some of the possible mechanisms through which luteolin exerts its therapeutic effects are the following: preventing DNA alterations in oncogene and tumor-suppressor genes, decreasing vascular endothelial growth factor (VEGF), inhibiting the elevation of reactive oxygen species (ROS), and downregulating inflammatory cytokines (TNF-α) and transcription factors (Nf-κB, STAT3) [21]. Here, VEGFA is linked to neoplasm.