A comparison of the amino acid profile between patients with glioma and the control group allowed for the identification of differences in both endogenous amino acids (SER, ARG, CIT, ASN, GLY, GABA, SAR, ABA, ORN, ASP) and exogenous amino acids (THR, MET, LYS, HIS, AAA, LEU, PHE, ILE, CC, TYR). This evidence concerns the gene CIT and central nervous system cancer.