Additionally, SPP1 can also recognize albumin (ALB), integrin-A (ITGAV) and integrin-B (ITGB1) proteins whose expression was found to be highly increased at an early stage of bladder cancer development, using the TCGA-BLCA search engine (Supplementary Figure S3B–E). The gene discussed is ITGB1; the disease is urinary bladder carcinoma.