Recent studies have claimed that higher prolactin levels in HNC can be a marker of poor prognosis [29], and in another study, levels of prolactin, estrogen, progesterone, and DHEAS were measured in male patients with tongue cancer, and the results demonstrated a decreased ratio of testosterone:estradiol and increased levels of FSH, LH, and prolactin, which align with other studies claiming that prolactin might have a role in tongue cancer. This evidence concerns the gene SULT2A1 and tongue cancer.