We found that mutations in FLT4, LRRC4C, PCDH15, FAM47B, PIK3CD, MAP3K15, PIK3R6, and SPOP, among others, were significantly enriched in LNM relative to primary tumor foci, suggesting natural selection for these somatic mutations in metastatic clones (Figure 3B). The gene discussed is PCDH15; the disease is neoplasm.