The upregulated gene set included oncogenes such as PIK3CB, FGFRL1, and NCOA2; prostate cancer-related genes such as SPON2, PCAT4, and SCHLAP1; and cell cycle genes such as MKI67, MCM4, KIF4A, CENPF, and FLNB. Here, SPON2 is linked to Familial prostate cancer.