Conversely, over-expression of KLF13 stimulated HCC xenograft growth in nude mice, in part, via induction of HMGCS-1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1), and thus enhanced synthesis of cholesterol [203] by the induction of the ACOT7 (Acyl-CoA Thioesterase 7) gene (encoding a tumor-promoting protein involved in fatty acid metabolism) [204]. This evidence concerns the gene ACOT7 and neoplasm.