In addition, KLF9 inhibits the transcription of the Notch1 gene in GBM neurosphere cells, resulting in the repression of Notch signaling and correspondingly reducing the expression of the Notch pathway genes HES1 (Hairy and Enhancer of Split-1) and related HES5 and HEY2 genes [154]. The gene discussed is KLF9; the disease is glioblastoma.