CD274 and colorectal neoplasm: These observations are intriguing, especially in view of the current immune therapies targeting PD-1/PD-L1, as well as the reported independent correlations of PD-L1 immunopositivity in colorectal tumor cells and conversely PD-L1 immunonegativity in colorectal tumor-infiltrating lymphocytes, with worse overall survival of CRC patients [175].