ZD55-AChE suppressed in vitro and in vivo cell growth in several GC cell lines without toxicity shown in normal gastric epithelial or primary fibroblast cells and more so than replication-deficient adenovirus Ad.AChELow MOIs of ZD55-AChE also cytotoxic for some pancreatic, colon, and liver cancer cell lines Mechanism of ZD55-AChE cell death partly by induction of mitochondria-based apoptosis. The gene discussed is ACHE; the disease is liver cancer.