Consistent with the Warburg hypothesis, which indicates cancer cells’ preference for glycolysis over oxidative phosphorylation for energy production, ATP depletion and cell demise in response to VC are primarily attributed to the hindered glycolysis caused by the VC-induced H2O2-mediated inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) activity [43,62]. The gene discussed is GAPDH; the disease is cancer.