Except for YBX1, TP53, TFDP1, STAT6, SIN3A, RELA, NFATC1, MED1, KLF5, CREB1, and ATF4, the other proteins show statistically significant differences in tumor versus non-tumor hepatic tissue; specifically, the TFs E2F1, FOXM1, PTTG1, BRCA1, E2F3, NFYA, IRF3, ZNF143, E2F4, and NFYB have high expression, and conversely, the genes NFKB1, SMAD7, IRF1, KLF4, and FOS are down-regulated in liver cancer tissues (Figure S5B). The gene discussed is CREB1; the disease is liver cancer.