Conversely, Wang et al. [14] pointed out that the signature composed by MARCO, CLEC4M, FCGR2B, LYVE1, TIMD4, STAB2, CFP, CLEC4G, CLEC1B, FCN2, FCN3, and FOXO1 reflects altered genes that may contribute to the pathogenesis of HCC, deserving a deep exploration. This evidence concerns the gene FCN3 and hepatocellular carcinoma.