These findings encourage potentiating the search aimed at developing small molecules able to specifically inhibit HSP110, as a promising strategy to impair the survival of not only PEL cells and other B cell lymphomas, such as BL [19], but possibly also solid cancer cells, such as colon cancer cells in which this HSP has been shown to play an important role in cell survival [30]. Here, HSPH1 is linked to B-cell non-Hodgkin lymphoma.