According to the driver gene analysis of the findings of the WES performed for the 21 C-NEC cases, TP53 (85.7%, 18/21), RB1 (42.9%, 9/21), and EGFR (42.9%, 9/21) were the most common molecular alterations (Figure 2, Supplementary Figure S1A). This evidence concerns the gene EGFR and neuroendocrine carcinoma.