CDKN1A and retinoblastoma: In retinoblastoma ARPE-19, HRMECs, Y79 cells, and the silencing of STAT3 by siRNA reduced cell proliferation and the expression of STAT3-related genes, such as BCL2, BCL2L1, BIRC5, MMP9, VEGFA, CCND1, cyclin-dependent kinase inhibitor 1A (CDKN1A), and MYC [147].