SMAD4 and colorectal carcinoma: Although CRC-PM differed in mutation frequency, the mutation pattern was similar to primary CRC: TP53 (median 54%, 33–75%), KRAS (45%, 20–58%), APC (44%, 31–57%), Smad4 (22%, 15–29%), BRAF (15%, 6–36%), and PIK3CA (13%, 9–14%) [26].