On the other hand, EGF and EGFR overexpression found in the ICI/TKI group has once more been implicated in silico with poorer outcomes [81] and presents another controversial answer to our questions since EGFR in ccRCC has been shown to be on the uptake even after EGFR-targeted therapies due to a variety of tumor-specific characteristics [82]. This evidence concerns the gene EGFR and nonpapillary renal cell carcinoma.