Immunoproteasome LMP2 and LMP7 subunits have been systematically detected in brain biopsies isolated post-mortem from subjects diagnosed with neurodegenerative conditions, e.g., Alzheimer’s disease (AD) and Huntington disease (HD) as well as in the cerebral cortex and hippocampus of a rodent model [117]. Here, PSMB8 is linked to Alzheimer disease.