Interestingly, lncRNA ZFAS1, one of the significant EMT inducers in CRC, promotes small nucleolar RNA-mediated 2′-O-methylation via NOP58 recruitment and is also responsible for CRC tumorigenesis and further progression via DDX21-POLR1B regulatory axis [33,51,52]. The gene discussed is DDX21; the disease is colorectal carcinoma.