Polarised M2 macrophages increase stemness and metastatic ability of CRC cells by secreting TGF-β2 and chemokine C-X-C-Motif Ligand 12 (CXCL12), which activates the WNT/β-catenin pathway, thus promoting EMT [43]. Here, CXCL12 is linked to colorectal carcinoma.