Top networking (top hub) proteins encoded by upregulated genes in the ABCC4 High CRC subgroup are mainly involved in the regulation of nearly all stages of RNA metabolism (transcription, pre-mRNA splicing, RNA export and translation), chromatin metabolism, transcription factors binding and construction of small nucleolar ribonucleoproteins (snoRNPs) complex (composed of core RNP proteins such as NOP58, and rRNA such as SNORD27, which facilitates 2′-O-Me of A27 on 18S rRNA) [33,44,45]. Here, SNORD27 is linked to colorectal carcinoma.