GNRH1 and cancer: ADT, a hormone therapy aimed at reducing androgen levels in the body or blocking their action on cancer cells, can be achieved through surgical removal of the testicles or medical therapies that suppress the production or action of androgens (e.g., luteinizing hormone-releasing hormone (LHRH) agonists and antagonists, which reduce testosterone production, and anti-androgens, which block the androgens on cancer cells).