In this scenario, the high clonal neoantigen fraction and clonal TMB in the HRP group could be induced to immune reactivity by Vigil®, which creates a permissive immunologic “training” environment for dendritic cells in the skin by presenting the entire antigen repertoire of the patient’s tumor in the presence of immunostimulatory GMCSF and reduced immunosuppressive TGFβ. Here, TGFB1 is linked to neoplasm.