For example, the antiproliferative effects of two mitochondria-targeted drugs, namely 3-carboxyl proxyl nitroxide (mito-CP) and mito-metformin, were mediated by a decrease in intracellular ATP levels, inhibition of ATP-linked oxygen consumption, activation of AMP-activated protein kinase (AMPK), and phosphorylation-associated suppression of the mTOR target ribosomal protein S6 kinase B1 (RPS6KB1 or p70S6K) in colon cancer cells [8]. This evidence concerns the gene RPS6KB1 and colonic neoplasm.