AFP and neoplasm: Data coming from analysis of the Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) registry confirmed that some pre-transplant factors are strong predictors of recurrence, including the presence of extrahepatic or lymph nodal spread (OR 6.8 and 1.9, respectively), poor tumor differentiation (OR 2.8), micro- and macrovascular invasion (OR 2.6 and 3.2, respectively), explant TNM stage T4 or T3 (OR 2.4 and 1.9, respectively), downstaging from a stage > than T2 (OR 1.8), and high AFP values (OR 1.2) [48].