In a prospective cohort of 285 patients transplanted according to Milan criteria, AFP-L3 and DCP resulted in the strongest predictors of HCC recurrence, and a combination of both (AFP-L3 ≥ 15% and DCP ≥ 7.5) predicted 61.1% of observed recurrence [54] (Figure 1). Here, AFP is linked to hepatocellular carcinoma.