Notably, the expression of RUNX1-positive hematopoietic progenitors did not vary significantly across all four patient groups, regardless of the presence of excess blasts in the advanced disease stages MDS-EB and GATA2-EB (mean ± SD in GATA2-RCC was 0.01459 ± 0.02384, GATA2-EB was 0.01924 ± 0.01474, RCC was 0.01806 ± 0.02900, and MDS-EB was 0.02243 ± 0.03122, Figure S2B). Here, GATA2 is linked to myelodysplastic syndrome.