Furthermore, while the influence of EZH2 and epigenetics in MDS has been extensively studied in adults [23,26,27,28,29], our findings of robust EZH2 expression associated with increased histone trimethylation in pediatric GATA2-EB patients contribute to the growing understanding of the influence of epigenetic factors on disease progression in children [30]. Here, EZH2 is linked to myelodysplastic syndrome.