Somatically mutated human genes known to be sites for productive HPV integration in cervical cancer include MAPK1, HLA-B, EP300, FBXW7, NFE2L2, TP53, ERBB2, SHKBP1, ERBB3, CASP8, HLA-A, TGFBR2, FBXW7, PIK3CA, FAT1, TP63, MECOM, TBL1XR1, NDN, GOLGA6L4, BAIAP3, TTN, MUC4, KMT2C, and SYNE1 [12,17,18,19,20,21,22]. The gene discussed is PIK3CA; the disease is cervical carcinoma.