The activation of the humoral immune system and the secretion of tumor cell-derived cytokines, such as tumor necrosis factor-alpha (TNF alpha), interferon-γ (IFN-γ), interleukin-1β (IL-1β), and interleukin-6 (IL-6) are part of the pathophysiology of cancer-related cachexia. This evidence concerns the gene TNF and neoplasm.