The mechanisms of canopy disruption are not fully understood, but it may be mediated by cancer-induced apoptosis of the canopy cells [11], as myeloma cells have been shown to induce apoptosis in osteoblastic cells via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas-Ligand (FasL) [87,88]. Here, FASLG is linked to plasma cell myeloma.