The most significant change in the pattern of management has been the use of TKIs to prevent the onset of brain metastases in patients with NSCLC with activating mutations in either the epidermal growth factor receptor (EGFR) gene, in case of anaplastic lymphoma kinase (ALK) gene rearrangement, or in Her-2/neu overexpressing breast cancer. This evidence concerns the gene EGFR and breast cancer.