A study investigated the effect of chemoradiotherapy (CRT) on the levels of APOA2 and revealed that the distribution of APOA2 isoforms in pancreatic ductal adenocarcinoma (PDAC) patients underwent significant changes before and after CRT, which were not linked to the treatment effectiveness, but rather to alterations in the pancreas morphological characteristics. Here, APOA2 is linked to pancreatic ductal adenocarcinoma.