As mentioned in Section 3, Lee and colleagues documented the inhibitory effect of GLS2 silencing on the proliferation of HepG2 cells derived from hepatocellular carcinoma (HCC) [75]; nevertheless, this is one of the few reports, if not the only one, suggesting a pro-oncogenic role for GLS2 in this tumor type. This evidence concerns the gene GLS2 and hepatocellular carcinoma.