Yet another protein that interacts with GLS2, at least in HCC cells, is Ras-related C3 botulinum toxin substrate 1 (Rac1), a member of the Rho GTPase family, involved in the regulation of tumor angiogenesis, invasion, and metastasis; these processes underlie malignant transformation. This evidence concerns the gene GLS2 and hepatocellular carcinoma.