GLS2 and non-small cell lung carcinoma: In the other model of NSCLC, A549 cells, GLS2 silencing decreased the cell proliferation; a similar effect was observed when the cells were treated with an alkyl benzoquinone 1-(5-methoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)pentadecan-2-yl acetate (AV-1) isolated from Ardisia virens, which preferentially inhibits GLS2 rather than GLS enzymes [75].