It is noteworthy that the transcription factor p63 belonging to the p53 family binds directly to the p53/p63 consensus DNA-binding sequence within the GLS2 promoter region and induces transcription of this gene [42]; moreover, Xiao and colleagues identified a Myc-binding site within the first intron of GLS2 and documented a direct activation of the transcription of this gene by N-Myc in MYCN-amplified neuroblastoma cells [43]. This evidence concerns the gene MYCN and neuroblastoma.