In fact, overexpression of the GLS gene has been documented in several cancer types of different origin and, in most cases, GAC is the predominant GLS isoform [15,16,17,18,19,20,21,22,23,24]; moreover, the silencing of GLS expression reversed the malignant phenotype of cancer cells both in vitro and in vivo, proving the important role GLS products play in promoting tumorigenesis [25,26,27,28,29,30]. This evidence concerns the gene GLS and cancer.