They diminished the clonogenic potential of human pancreas adenocarcinoma AsPC-1 cells and reduced the tumor size formed by AsPC-1 in mice; however, even though some of them inhibited GLS2 (e.g., compound 6 had an IC50 value of 102 nM), they were more selective against GLS (IC50 value of 50 nM) [90], clearly indicating that further studies are required to develop GLS2-specific inhibitors. The gene discussed is GLS2; the disease is pancreatic adenocarcinoma.