Also findings a moderate to strong positive correlation of serum periostin with B2MG, BMI, creatinine, and TP, as well as a negative correlation with albumin and Hb, all of which are associated with disease progression, we suggest the important role of periostin for MPC invasion in the BM and for MBD. The gene discussed is GSTM1; the disease is Marchiafava-Bignami disease.