Finally, in a mouse model of alcoholic HCC (Lieber–DeCarli alcohol diet + intraperitoneal injection of DEN), miR-122 expression is downregulated [54], thus leading to the overexpression of cyclin G1 and hypoxia-inducible factor 1-alpha (HIF1α) expression, two direct targets of this miRNA involved in cancer cell proliferation and invasion [54]. Here, HIF1A is linked to cancer.