The levels of HIF-1α protein expression in tumor tissue sections from the four groups are shown in Figure 7A. In three individual murine models, HIF-1α protein levels were significantly lower in group 4 than those in group 1 (G06A; p = 0.0062, J3TBg; p = 0.0248 and SDT3G; p = 0.00784), and there were no significant differences among groups 1, 2, and 3. This evidence concerns the gene HIF1A and neoplasm.