As a result of the intrinsic activity of the SEMA6B–plexin-A4–FGFR1/VEGFR2 axis, endothelial cells (HUVECs) and U87MG glioblastoma cells acquired pro-proliferative stimuli that assembled for pro-angiogenic and pro-tumorigenic signaling in the tumor microenvironment. Here, SEMA6B is linked to neoplasm.