CD274 and cancer: As shown in Figure 5, subjects in cluster 4M0-Hi had significantly lower tumoral PD-L1 expression (Kruskal–Wallis p = 0.00011; Figure 5a), a significantly higher T-cell exclusion signature (Kruskal–Wallis p = 6.3 × 10−10; Figure 5b), and significantly higher cancer-associated fibroblast (CAF) transcriptomic signatures (Kruskal–Wallis p = 2.2 × 10−16; Figure 5c) and myeloid-derived suppressor cells (MDSCs) (Kruskal–Wallis p = 6.3 × 10−5; Figure 5d) in the stroma.