Bone loss is mainly caused by the activation of osteoclastogenesis via the RANK/RANKL (receptor activator of nuclear factor kappa-B ligand) signaling in response to proinflammatory and proosteolytic cytokines such as interleukin-1, 6, and tumor necrosis factor-α secreted by cancer cells [19]. Here, TNFRSF11A is linked to cancer.