In multiple myeloma models, Caracciolo et al. [81] demonstrated the effectiveness of PARPi olaparib in the treatment of MYC-proficient cells, with a similar pattern of DNA-damage and cell death seen after PARP1 knockout, suggesting a synthetic lethality model correlating the axis MYC-PARP1. The gene discussed is PARP1; the disease is AL amyloidosis.