Both cell lines Raji and Namalwa have a significantly lower expression of PARP1 compared with the ALL cell line, SUP-B15, and the lack of response to the treatment with PARPi is in accordance with the previously reported dependence of PARP1 for proper PARPi cytotoxic effectiveness [54], although Raji still overexpresses in comparison to the non-neoplastic control (Figure 1). Here, PARP1 is linked to acute lymphoblastic leukemia.