The results indicate that AZD2461 acts over apoptosis induction much more prematurely than imatinib in this model of ALL p190+; however, data interpretation must take into account the aforementioned presence of a tumor hypodiploid subpopulation and the potential cytotoxic effect of AZD2461 over this population, raising the hypothesis if AZD2461 actually induces early apoptosis over the cell line as a whole or over specific and differentiated neoplastic clones. Here, CNTNAP1 is linked to acute lymphoblastic leukemia.