In this situation, and considering the genomic instability associated with BCR::ABL1 presence [8], the inhibition of PARP through the use of AZD2461, with consequent deregulation of DDR pathways, was shown to be highly disruptive to the maintenance of cell homeostasis, inducing considerable loss of viability in this model representative of Ph+ ALL. The gene discussed is PARP1; the disease is acute lymphoblastic leukemia.