However, although this implies the presence of functional redundancies of LARP isoforms, by simultaneous depletion of these three LARP proteins (LARP1, -4, and -4B), a considerable proliferation disadvantage was observed (Figure 6C), highlighting the critical role of LARP proteins as indispensable factors in MM cell proliferation. This evidence concerns the gene LARP1 and Miyoshi myopathy.