Treatment of NSCLC cells with nicotine led to downregulation of GABA synthesis, an effect reversed by cell co-treatment with the α4β2nAChR antagonist N-n-decylnicotinium iodide (NDNI), while cell treatment with GABA blocked β-AR signaling and cell proliferation [23]. The gene discussed is ADRB2; the disease is non-small cell lung carcinoma.