The treatment of NSCLC cells with nicotine resulted in increased levels of adrenaline, noradrenaline, VEGF, and activities of PI3K, AKT, NFκB, and also inhibited p53 activity via a mechanism involving α7nAChR, α4β2nAChR, and β-ARs, leading to decreased apoptosis and increased cell survival. Here, TP53 is linked to non-small cell lung carcinoma.