Univariate Cox regression analysis revealed a significant correlation between the OS of HNSCC patients and several TCRRGs, namely CSF2, INPP5D, MAP2K1, MAP2K7, MAPK3, MAPK9, ORAI1, PIK3R3, PSMA1, PSMA7, PSMD10, PSMD2, PSMD7, SKP1, UBB, UBE2D2, and ZAP70 (Table 1). This evidence concerns the gene MAPK3 and head and neck squamous cell carcinoma.