IL-6 binding to cancer cells is capable of initiating several mitogenic signaling cascades via activation of the PI3K/Akt, ERK/MAPK, and the JNK/STAT3 pathways, resulting in increased cancer cell survival, proliferation, malignant transformation and dedifferentiation, migration, and invasion [109,110,111,112,113,114]. This evidence concerns the gene MAPK8 and cancer.