GSK3B and chronic myelogenous leukemia, BCR-ABL1 positive: Moreover, CML patients display a mis-splicing of GSK-3β RNA, leading to the deletion of exons 8 and 9, and resulting in a truncated form of GSK-3β that lacks the axin binding domain, thereby preventing β-catenin phosphorylation and proteasomal degradation, hence, excessive and protracted Wnt pathway activation [7].